Remarkable Ligand Effect on Rh-Catalyzed C–H-Active [3 + 2] Annulation of Ketimines and Alkynes
Yan Shi, Yong Fang, Xu Zhao, Chengfeng Zhu, Xiang Wu, Xiaoming Yang, Yunfei Luo
Abstract
Externally added ligands were first found to have a significant impact on the Rh-catalyzed C–H-active [3 + 2] annulation of ketimines and alkynes. Olefin ligands have shown remarkable promotion effect for this reaction. The olefin promoted the reaction by increasing both the turnover rate and conversion of [Cp*RhCl2]2 in the formation of rhodacycle in the C–H activation step.
Topics & Concepts
ChemistryAnnulationCatalysisOlefin fiberLigand (biochemistry)Medicinal chemistryStereochemistryCombinatorial chemistryOrganic chemistryReceptorBiochemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsCatalytic Alkyne Reactions