MAPK p38/Ulk1 pathway inhibits autophagy and induces IL-1β expression in hepatic stellate cells
Li Jin, Juan Li, Shujuan Yang, Rou Zhang, Chunhua Hu, Yi Chen, Zhen Tian, Wenqi Ma, Yali Feng, Na Liu, JinFeng Liu, Yuan Yang, Tianyan Chen, YingRen Zhao, Yingli He, Taotao Yan
Abstract
LPS inhibits autophagy in a concentration- and dose-dependent manner in HSC-T6 cells. MAPK p38 induces phosphorylation of Ulk1, which disrupts the Ulk1-Atg13 complex and is therefore required for the inhibition of autophagy by LPS. LPS induces IL-1β expression via the MAPK p38/Ulk1 pathway in HSCs.
Topics & Concepts
AutophagyAutophagy-related protein 13Cell biologyULK1p38 mitogen-activated protein kinasesMAPK/ERK pathwayHepatic stellate cellPhosphorylationInflammationBiologyImmune systemProtein kinase ACancer researchImmunologyBiochemistryProtein phosphorylationEndocrinologyApoptosisAMPKAutophagy in Disease and TherapyLiver physiology and pathologyPhagocytosis and Immune Regulation