Dual-targeting CAR-T cells with optimal co-stimulation and metabolic fitness enhance antitumor activity and prevent escape in solid tumors
Koichi Hirabayashi, Hongwei Du, Yang Xu, Peishun Shou, Xin Zhou, Giovanni Fucà, Elisa Landoni, Chuang Sun, Yu‐Hui Chen, Barbara Savoldo, Gianpietro Dotti
Topics & Concepts
Chimeric antigen receptorCD28Cancer researchAntigenCell biologyT cellCytotoxic T cellBiologyCo-stimulationImmunologyImmune systemIn vitroBiochemistryCAR-T cell therapy researchImmune Cell Function and InteractionNanowire Synthesis and Applications