A Convenient Way to Quinoxaline Derivatives through the Reaction of 2-(3-Oxoindolin-2-yl)-2-phenylacetonitriles with Benzene-1,2-diamines
А. В. Аксенов, Nikolai A. Arutiunov, Дмитрий А. Аксенов, Artem V. Samovolov, Igor A. Kurenkov, Nicolai A. Aksenov, E. A. Aleksandrova, Daria S. Momotova, Michael Rubin
Abstract
Microwave-assisted reaction between 2-(3-oxoindolin-2-yl)-2-phenylacetonitriles andbenzene-1,2-diamines leads to the high-yielding formation of the corresponding quinoxalines as sole, easily isolaable products. The featured transformation involves unusual extrusion of phenylacetonitrile molecule and could be performed in a short sequence starting from commonly available indoles and nitroolefins.
Topics & Concepts
QuinoxalineChemistryCombinatorial chemistryMoleculeIndole testBenzeneOrganic chemistryMedicinal chemistryStereochemistrySynthesis and Biological EvaluationSynthesis and Reactions of Organic CompoundsFluorine in Organic Chemistry