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ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism

Sarah T. Boyle, Valentina Poltavets, Jasreen Kular, Natasha T. Pyne, Jarrod J. Sandow, Alexander C. Lewis, Kendelle J. Murphy, Natasha Kolesnikoff, Paul A.B. Moretti, Melinda N. Tea, Vinay Tergaonkar, Paul Timpson, Stuart M. Pitson, Andrew I. Webb, Robert J. Whitfield, Angel F. López, Marina Kochetkova, Michael S. Samuel

2020Nature Cell Biology102 citationsDOI

Topics & Concepts

Paracrine signallingTumor microenvironmentCancer researchCancerCancer-Associated FibroblastsKinaseCell biologyReprogrammingCancer cellEndoplasmic reticulumBiologyMedicineInternal medicineCellReceptorTumor cellsGeneticsEndoplasmic Reticulum Stress and DiseasePhagocytosis and Immune RegulationFibroblast Growth Factor Research
ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism | Litcius