MicroRNAs in hematopoietic stem cell aging
Daniëlle Luinenburg, Gerald de Haan
Abstract
The functional decline that is observed in HSCs upon aging is attributed mainly to cell intrinsic factors that regulate quiescence, self-renewal and differentiation. MicroRNAs (miRs) have an indispensable role in the regulation of HSCs and have been shown to also regulate processes related to tissue aging in specific cell types. Here we discuss the role of miRs in the regulation of HSC self-renewal and differentiation throughout life and its implications for future research.
Topics & Concepts
microRNAStem cellHaematopoiesisBiologyCell biologySenescenceHematopoietic stem cellCellular differentiationCellGeneticsGeneMicroRNA in disease regulationExtracellular vesicles in diseaseMesenchymal stem cell research