Metal-free, <i>tert</i>-butyl nitrite promoted C(sp<sup>2</sup>)–S coupling reaction: the synthesis of aryl dithiocarbamates and analysis of antimicrobial activity by ‘<i>in silico</i>’ and ‘<i>in vitro</i>’ methods for drug modification
Satyajit Pal, Subhankar Kumar Sarkar, Anindita Mukherjee, Anupam Kundu, Animesh Sen, Jnanendra Rath, Sougata Santra, Grigory V. Zyryanov, Adinath Majee
Abstract
An environmentally friendly, metal-free, and efficient C(sp 2 )–S coupling reaction protocol between aniline and low-cost tetraalkylthiuram disulfides was developed to synthesize aryl dithiocarbamates.
Topics & Concepts
ChemistryAntimicrobialArylCombinatorial chemistryIn vitroNitriteMetalCoupling reactionOrganic chemistryMedicinal chemistryBiochemistryCatalysisNitrateAlkylSulfur-Based Synthesis TechniquesSynthesis and Catalytic ReactionsChemical Synthesis and Reactions