Impact of aliphatic acyl and aromatic thioamide substituents on the anticancer activity of Ru(<scp>ii</scp>)-<i>p</i>-cymene complexes with acylthiourea ligands—<i>in vitro</i> and <i>in vivo</i> studies
Srividya Swaminathan, Jebiti Haribabu, Mohamed Kasim Mohamed Subarkhan, D. Gayathri, Nithya Balakrishnan, Nattamai Bhuvanesh, César Echeverría, Ramasamy Karvembu
Abstract
Six acylthiourea-based Ru( ii )- p -cymene complexes (P1–P6) were designed to explore the structure–activity relationship of the complexes under the influence of aliphatic chain length and aromatic conjugation on the C- and N-terminals, respectively.
Topics & Concepts
ChemistryDenticityStereochemistryAlkylKinaseLipophilicityCisplatinIn vitroMAPK/ERK pathwayMedicinal chemistryCrystal structureBiochemistryCrystallographyOrganic chemistryChemotherapySurgeryMedicineMetal complexes synthesis and propertiesSynthesis and biological activityComputational Drug Discovery Methods