Preparation, characterization, and optimization of asenapine maleate mucoadhesive nanoemulsion using Box-Behnken design: In vitro and in vivo studies for brain targeting
Santosh Ashok Kumbhar, Chandrakant Kokare, Birendra Shrivastava, Bapi Gorain, Hira Choudhury
Topics & Concepts
Nasal administrationMucoadhesionIn vivoEx vivoPharmacologyBox–Behnken designPharmacokineticsBlood–brain barrierDrug deliveryBioavailabilityChemistryIn vitroDrugMaterials scienceDrug carrierMedicineNanotechnologyChromatographyResponse surface methodologyCentral nervous systemBiochemistryBiologyInternal medicineBiotechnologyAdvanced Drug Delivery SystemsAdvancements in Transdermal Drug DeliveryNanoparticle-Based Drug Delivery