Photoinduced Defluorinative Branch-Selective Olefination of Multifluoro (Hetero)arenes
Ye Yuan, Muliang Zhang, Xiaodong Tang, Jared L. Piper, Zhi-Hui Peng, Jun‐An Ma, Jie Wu, Fa‐Guang Zhang
Abstract
We report a photoredox platform for constructing styrenyl polyfluoro (hetero)arenes with branch selectivity by taking advantage of sulfinate as both a radical-relay precursor and a sacrificial nucleofuge. This protocol merges photoredox catalysis with radical-radical coupling and an elimination process in a one-pot operation and features good functional group tolerance, mild conditions, and a facile method to access polyfluoro (hetero)aryl derivatives of natural products and drugs.
Topics & Concepts
ChemistryFunctional groupArylCombinatorial chemistrySelectivityCatalysisAryl radicalCoupling (piping)PhotochemistryOrganic chemistryMechanical engineeringAlkylPolymerEngineeringFluorine in Organic ChemistryRadical Photochemical ReactionsSulfur-Based Synthesis Techniques