Vanadium selenide encapsulated β-Cyclodextrin/rGO nanosheets: An effective electrochemical detection of antibiotic in environmental aquatic and biological samples
Kuo‐Yuan Hwa, Aravindan Santhan, Anindita Ganguly, Ravikumar Murugan
Abstract
Background Antibiotic identification with precision is crucial. Vanadium selenide (V 3 Se 4 ) was synthesized and later encapsulated onto the beta-cyclodextrin/reduced graphene oxide nanosheets (β-CDN/rGONs) to achieve efficient electrochemical sensing of moxifloxacin hydrochloride (MFH) in water and biological samples. Due to their unique characteristics as composite structures, transition metal chalcogenides (TMDs) with carbon composite (V 3 Se 4 / β-CDN/rGONs) were produced. Methods The structural and functional analysis by X-ray diffraction, Fourier transform infrared spectroscopy, and X-ray photoelectron spectroscopy revealed the crystalline purity and the successful formation of the composite material. Transmission electron microscopy were done to study the morphological properties of the material. The morphological analysis revealed spherical structure of the (V 3 Se 4 ) material and wrinkled sheets of β-CDN/rGONs. Significant Findings The V 3 Se 4 /β-CDN/rGONs modified glassy carbon electrode (GCE) has been subjected to electrochemical sensing. A sensor for detecting MFH antibiotics employing cyclic voltammetry (CV) and differential pulse voltammetry (DPV) was developed. The DPV investigation has a low limit of detection (LOD) 15.2 nM, a wide linear range about 0.02 μM to 873.3 μM, and with the sensitivity of 1.87 μA μM -1 cm 2 . The sensor's performance demonstrated good analyte recovery rates for real sample measurement in biological and environmental aquatic samples. The findings indicated that the sensor performs well at detecting MFH and has the potential for future applications.