A doxorubicin–platinum conjugate system: impacts on PI3K/AKT actuation and apoptosis in breast cancer cells
Patel Puja, Devan Umapathy, Selvambigai Manivannan, Vinita Manimaran Nadar, Rajiu Venkatesan, Velanganni Antony Joseph Arokiyam, Srinivasan Pappu, Ponnuchamy Kumar
Abstract
was activated, which led to the stimulation of a mitochondrion-based intrinsic apoptotic pathway and its downstream caspases, triggering cell death. Hence, our findings suggested that a biologically stable doxorubicin-platinum conjugate system could be an imperative therapeutic agent for anticancer therapy in the near future.
Topics & Concepts
ConjugateDoxorubicinApoptosisProtein kinase BPlatinumPI3K/AKT/mTOR pathwayBreast cancerCancer researchChemistryCancerInternal medicineBiochemistryBiologyMedicineChemotherapyMathematicsMathematical analysisCatalysisChemotherapy-induced cardiotoxicity and mitigationNanoparticle-Based Drug DeliverySynthesis and biological activity