Inhibition of GPR17 with pranlukast protects against TNF-α-induced loss of type II collagen in ATDC5 cells
Zhangfu Wang, Weiwei Zhou, Guangbin Zheng, Guangyong Yang
Topics & Concepts
Matrix metalloproteinaseInflammationProinflammatory cytokineOxidative stressPharmacologyTumor necrosis factor alphaGene knockdownReactive oxygen speciesReceptorMedicineType II collagenSignal transductionChemistryArthritisImmunologyEndocrinologyInternal medicineBiochemistryApoptosisInflammatory mediators and NSAID effectsEstrogen and related hormone effectsNF-κB Signaling Pathways