RNA Captures More Cations than DNA: Insights from Molecular Dynamics Simulations
Sergio Cruz-León, Nadine Schwierz
Abstract
, the simulations allow us to reveal the ion-specific distributions and binding patterns for DNA and RNA duplexes. The microscopic insights from the simulations display the origin of ion-specificity and shed light on the question of why DNA and RNA show opposing behavior in the same ionic conditions. Finally, the detailed binding patterns from the simulations reveal why RNA can capture more cations than DNA.
Topics & Concepts
Nucleic acidBiomoleculeRNAMolecular dynamicsDivalentDNAChemistryValencyIonChemical physicsNucleic acid structureIonic bondingDNA condensationBiophysicsComputational chemistryBiochemistryBiologyOrganic chemistryTransfectionGenePhilosophyLinguisticsDNA and Nucleic Acid ChemistryRNA and protein synthesis mechanismsNanopore and Nanochannel Transport Studies