BL-918, a small-molecule activator of ULK1, induces cytoprotective autophagy for amyotrophic lateral sclerosis therapy
Wei Liu, Shiou Zhu, Yulin Guo, Long‐Fang Tu, Yongqi Zhen, Rongyan Zhao, Liang Ouyang, Hiroshi Kurihara, Rong‐Rong He, Bo Liu
Topics & Concepts
AutophagyAmyotrophic lateral sclerosisULK1SOD1Activator (genetics)PharmacologyMedicinePathogenesisIn vivoChemistryKinaseImmunologyBiologyProtein kinase ABiochemistryReceptorApoptosisInternal medicineDiseaseAMPKBiotechnologyAmyotrophic Lateral Sclerosis ResearchAutophagy in Disease and TherapyParkinson's Disease Mechanisms and Treatments