The Role of Genetic Sex and Mitochondria in Response to COVID-19 Infection
Małgorzata Kloc, Rafik M. Ghobrial, Jacek Z. Kubiak
Abstract
The difference between the female and male immune response to COVID-19 infection, and infections in general, is multifactorial. The well-known determiners of the immune response, such as X and Y chromosomes, sex hormones, and microbiota, are functionally interconnected and influence each other in shaping the organism's immunity. We focus our commentary on the interplay between the genetic sex and mitochondria and how this may affect a sex-dependent immune response in COVID-19 infection. Realizing the existence of these interactions may help in designing novel methods or fine-tuning the existing and routine therapies to fight COVID-19 and other infections.
Topics & Concepts
Immune systemImmunologyBiologyCoronavirus disease 2019 (COVID-19)ImmunityOrganismMitochondrionDiseaseMedicineGeneticsInfectious disease (medical specialty)Internal medicineGenetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesSex and Gender in HealthcareReproductive System and Pregnancy