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Design, synthesis, and biological evaluation of new 2-(4-(methylsulfonyl)phenyl)-N-phenylimidazo[1,2-a]pyridin-3-amine as selective COX-2 inhibitors

Mahsa Azami Movahed, Fatemeh Abbası, Mahsa Rajabi, Niusha Abedi, Nima Naderi, Bahram Daraei, Afshin Zarghi

2023Medicinal Chemistry Research12 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryPharmacophoreStereochemistryAmine gas treatingActive siteSelectivityEnzymeHydrogen bondArachidonate 5-lipoxygenaseArachidonic acidMoleculeOrganic chemistryCatalysisSynthesis and biological activityInflammatory mediators and NSAID effectsSynthesis and Reactions of Organic Compounds
Design, synthesis, and biological evaluation of new 2-(4-(methylsulfonyl)phenyl)-N-phenylimidazo[1,2-a]pyridin-3-amine as selective COX-2 inhibitors | Litcius