Therapeutic targeting of RBPJ, an upstream regulator of ETV6 gene, abrogates ETV6-NTRK3 fusion gene transformations in glioblastoma
Angana Biswas, Y. Rajesh, Subhayan Das, Indranil Banerjee, Neelkamal Kapoor, Pralay Mitra, Mahitosh Mandal
Topics & Concepts
Fusion geneETV6Fusion proteinBiologyEnhancerCancer researchTranscription factorGeneMolecular biologyGeneticsChromosomal translocationRecombinant DNAMelanoma and MAPK PathwaysProtein Degradation and InhibitorsGlioma Diagnosis and Treatment