Highly efficient photocontrolled targeted delivery of siRNA by a cyclodextrin-based supramolecular nanoassembly
Feng‐Qing Li, Qilin Yu, Yaohua Liu, Yaohua Liu, Hua‐Jiang Yu, Yong Chen, Yu Liu, Yu Liu
Abstract
In this study, we have constructed a binary supramolecular nanoassembly composed of α-cyclodextrin-modified hyaluronic acid and an azobenzene-modified diphenylalanine derivative with a positively charged imidazole group. This nanoassembly can bind with siRNA through electrostatic interactions and efficiently delivered them into cancer cells and inhibited their growth.
Topics & Concepts
CyclodextrinSupramolecular chemistryNanotechnologyChemistryCombinatorial chemistryMaterials scienceMoleculeBiochemistryOrganic chemistryRNA Interference and Gene DeliverySupramolecular Self-Assembly in MaterialsAdvanced biosensing and bioanalysis techniques