Upregulation of PKR pathway mediates glucolipotoxicity induced diabetic cardiomyopathy in vivo in wistar rats and in vitro in cultured cardiomyocytes
Sureshbabu Mangali, Audesh Bhat, Kirtikumar B. Jadhav, Jaspreet Kalra, Dharmarajan Sriram, Venkata Vamsi Krishna Venuganti, Arti Dhar
Topics & Concepts
Diabetic cardiomyopathyProtein kinase RInflammationOxidative stressDownregulation and upregulationEndocrinologyInternal medicineFibrosisSirius RedProinflammatory cytokineGene knockdownMedicineMyocardial fibrosisUnfolded protein responseApoptosisBiologyProtein kinase ACardiomyopathyKinaseCell biologyHeart failureBiochemistryMitogen-activated protein kinase kinaseGeneCardiovascular Function and Risk FactorsDiabetes Treatment and ManagementPancreatic function and diabetes