Litcius/Paper detail

High-density brush-shaped polymer lipids reduce anti-PEG antibody binding for repeated administration of mRNA therapeutics

Yufen Xiao, Xizhen Lian, Yehui Sun, Yun‐Chieh Sung, Amogh Vaidya, Zexiang Chen, Ankit Gupta, Sumanta Chatterjee, Lining Zheng, Erick Guerrero, Xu Wang, Lukas Farbiak, Yangyang Yang, Marc I. Diamond, Cecília Leal, Jeffrey G. McDonald, Daniel J. Siegwart

2025Nature Materials58 citationsDOIOpen Access PDF

Topics & Concepts

PEG ratioBrushAntibodyPolymerMessenger RNAChemistryMaterials scienceBiophysicsChemical engineeringBiochemistryMedicineImmunologyBiologyGeneOrganic chemistryComposite materialFinanceEngineeringEconomicsRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniquesVirus-based gene therapy research