Activation and selectivity of OTUB-1 and OTUB-2 deubiquitinylases
Dakshinamurthy Sivakumar, Vikash Kumar, Michael Naumann, Matthias Stein
Abstract
formed a stable hydrogen bond. We propose that the observed differences in activation kinetics, protonation states, water channels, and active-site accessibility between OTUB1 and OTUB2 may be relevant for the selective design of OTU inhibitors.
Topics & Concepts
SelectivityChemistryBusinessBiochemistryCatalysisUbiquitin and proteasome pathwaysPeptidase Inhibition and AnalysisCancer-related gene regulation