BK Polyomavirus Evades Innate Immune Sensing by Disrupting the Mitochondrial Network and Promotes Mitophagy
Julia Manzetti, Fabian H. Weissbach, Fabrice E. Graf, Gunhild Unterstab, Marion Wernli, Helmut Hopfer, Cinthia B. Drachenberg, Christine Hanssen Rinaldo, Hans H. Hirsch
Abstract
-treatment. Mitochondrial fragmentation and p62/SQSTM1-autophagy occur in allograft biopsies of kidney transplant patients with BKPyV nephropathy. JCPyV and SV40 infection similarly disrupt mitochondrial networks, indicating a conserved mechanism facilitating polyomavirus persistence and post-transplant disease.
Topics & Concepts
MitophagyBiologyVirologyInterferonViral replicationInnate immune systemMitochondrionImmune systemMitochondrial DNAImmunologyAutophagyVirusCell biologyGeneticsGeneApoptosisPolyomavirus and related diseasesCytomegalovirus and herpesvirus researchFull-Duplex Wireless Communications