NRF2 promotes radiation resistance by cooperating with TOPBP1 to activate the ATR-CHK1 signaling pathway
Xiaohui Sun, Mingxin Dong, Jiale Li, Yuxiao Sun, Yu Gao, Yan Wang, Liqing Du, Yang Liu, Kaihua Ji, Ningning He, Jinhan Wang, Manman Zhang, Huijuan Song, Chang Xu, Qiang Liu
Abstract
This study explored the novel role of NRF2 in promoting radiation resistance by cooperating with RPA32 and TOPBP1 to activate the ATR-CHK1 signaling pathway. In addition, the findings of this study not only provide novel insights into the molecular mechanisms underlying the radiation resistance of lung cancer cells but also validate NRF2 as a potential target for radiotherapy.
Topics & Concepts
RadioresistanceDNA damageDNA repairCancer researchBiologyLung cancerCancer cellCancerMolecular biologyCell biologyDNAMedicinePathologyCell cultureGeneticsDNA Repair MechanismsGenomics, phytochemicals, and oxidative stressCancer therapeutics and mechanisms