Glutamate Dehydrogenase (GdhA) of Streptococcus pneumoniae Is Required for High Temperature Adaptation
Ozcan Gazioglu, Banaz O. Kareem, Muhammad Afzal, Sulman Shafeeq, Oscar P. Kuipers, Andrew T. Ulijasz, Peter W. Andrew, Hasan Yesilkaya
Abstract
During its progression from the nasopharynx to other sterile and nonsterile niches of its human host, Streptococcus pneumoniae must cope with changes in temperature. We hypothesized that the temperature adaptation is an important facet of pneumococcal survival in the host.
Topics & Concepts
VirulenceBiologyStreptococcus pneumoniaeMicrobiologyPneumolysinTranscriptomeGeneBiofilmGlutamate dehydrogenaseMicroarrayStreptococcaceaeAdaptation (eye)Microarray analysis techniquesGalleria mellonellaPneumococcal infectionsGene expressionCLPBBacteriaDownregulation and upregulationFormate dehydrogenasePathogenRegulation of gene expressionDehydrogenaseHuman pathogenBacterial geneticsEscherichia coliPneumonia and Respiratory InfectionsNeonatal Respiratory Health ResearchTuberculosis Research and Epidemiology