The ORF7a protein of SARS-CoV-2 initiates autophagy and limits autophagosome-lysosome fusion via degradation of SNAP29 to promote virus replication
Peili Hou, Xuefeng Wang, Hongmei Wang, Tiecheng Wang, Zhangping Yu, Chunqing Xu, Yudong Zhao, Wenqi Wang, Yong Zhao, Fengyun Chu, Huasong Chang, Hongchao Zhu, Jiahui Lu, Fuzhen Zhang, Xue Liang, Xingyu Li, Song Wang, Yuwei Gao, Hongbin He
Abstract
: tissue culture infectious dose; TEM: transmission electron microscopy; TUBB, tubulin, beta; ULK1: unc-51 like autophagy activating kinase 1.
Topics & Concepts
AutophagyBiologyBAG3AutophagosomeCell biologyAutophagy-related protein 13Sequestosome 1LysosomePI3K/AKT/mTOR pathwayCoronavirusULK1VirologyKinaseProtein kinase ASignal transductionAMPKBiochemistryApoptosisDiseaseCoronavirus disease 2019 (COVID-19)Infectious disease (medical specialty)MedicinePathologyProtein phosphorylationEnzymeAutophagy in Disease and TherapyExtracellular vesicles in diseasePhagocytosis and Immune Regulation