Cell-cycle-dependent phosphorylation of RRM1 ensures efficient DNA replication and regulates cancer vulnerability to ATR inhibition
Zhen Shu, Zhen Li, Huanhuan Huang, Yan Chen, Jun Fan, Li Yu, Zhihui Wu, Ling Tian, Qi Qi, Shuang Peng, Changyong Wei, Zhongqiu Xie, Xiaobo Li, Feng Qi, Hao Sheng, Guangqiang Li, Dongping Wei, Changliang Shan, Guo Chen
Topics & Concepts
Ribonucleotide reductaseBiologyDNA replicationHeterotetramerDNA synthesisPhosphorylationEukaryotic DNA replicationDNA repairGenome instabilityCell cycleDNA damageDNA re-replicationCell biologyBiochemistryDNAProtein subunitCellGeneDNA Repair MechanismsMetal-Catalyzed Oxygenation MechanismsRNA modifications and cancer