Case Report: Telitacicept in severe myasthenia gravis: a case study with multiple autoantibodies
Qian Guo, Yusen Huang, Fangruyue Wang, Le Fang
Abstract
Multi-antibody-positive myasthenia gravis (MG) presentations are relatively rare, often found in older patients, and generally predict a poor prognosis. We report a case of a female patient with generalized MG, testing positive for Titin antibodies (Titin-Ab), ryanodine receptor antibodies (RyR-Ab), and acetylcholine receptor antibodies (AChR-Ab), and resistant to acetylcholinesterase inhibitors. Following unsuccessful traditional therapies, she received Telitacicept, leading to significant improvements. This case underscores Telitacicept's potential efficacy for similar patients and offers insights into the clinical characteristics of multi-antibody MG.
Topics & Concepts
Myasthenia gravisTitinAutoantibodyRyanodine receptorAcetylcholine receptorAntibodyMedicineAcetylcholinesteraseImmunologyInternal medicineReceptorChemistryEnzymeMyocyteBiochemistrySarcomereMyasthenia Gravis and ThymomaPeripheral Neuropathies and DisordersAntifungal resistance and susceptibility