miR-23b-3p rescues cognition in Alzheimer’s disease by reducing tau phosphorylation and apoptosis via GSK-3β signaling pathways
Hailun Jiang, Jianghong Liu, Shuilong Guo, Li Zeng, Zhongdi Cai, Junxia Zhang, Linlin Wang, Zhuorong Li, Rui Liu
Abstract
generation, and neuronal apoptosis, resulting in the suppression of the GSK-3β/p-tau and Bax/caspase-3 pathways. Collectively, our findings strongly support the hypothesis that miR-23b-3p plays a neuroprotective role in AD, thereby identifying miR-23b-3p as a promising therapeutic target for AD.
Topics & Concepts
PhosphorylationApoptosisSignal transductionDiseaseCognitionNeuroscienceGSK-3Cell biologyChemistryCancer researchBiologyMedicineInternal medicineBiochemistryAlzheimer's disease research and treatmentsMicroRNA in disease regulation