Therapeutic combination of gold nanoparticles and LPS as cytotoxic and apoptosis inducer in breast cancer cells
Ali M. Sameen, Majid S. Jabir, Mohammed Q. Al‐Ani
Abstract
The aims of this study are to use Gold nanoparticles (GNPs) and LPS as combination cytotoxic therapy In-vitro against MCF-7 cells. The GNPs was confirmed using SEM. MCF-7 cells were treated with GNPs, and LPS at different concentration then anti-proliferative activity of these substances was studied using MTT assay. Apoptotic cells were studied using Acrydin Orange /Ethidum bromide AO/EB daul stain. Our results showed the ability of GNPs, and LPS as potential anticancer agent in breast cancer that ability inducing apoptosis. The results of current work suggest that the GNPs and LPS could be used for wide biomedical applications in future and could be offer new drug instead of chemotherapy in treatment of various types of cancer disease.