Statin Initiation and Risk of Incident Alzheimer Disease and Cognitive Decline in Genetically Susceptible Older Adults
Kumar B. Rajan, Elizabeth A. McAninch, Robert S. Wilson, Anisa Dhana, Sara Evans‐Lacko, Denis A. Evans
Abstract
BACKGROUND AND OBJECTIVES: ε4 allele. METHODS: This population-based longitudinal cohort study was conducted in 4 urban communities in Chicago, IL, United States, consisting of 4,807 participants. Statin initiation is based on the inspection of medications during home assessments. Clinical diagnosis for incident AD used the NINCDS-ADRDA criteria, and longitudinal measurements of global cognition consisted of episodic memory, perceptual speed, and the Mini-Mental State Examination tests. RESULTS: ε4 allele. DISCUSSION: ε4 allele. CLASSIFICATION OF EVIDENCE: -e4 allele.
Topics & Concepts
Hazard ratioApolipoprotein EMedicineCognitive declineDementiaInternal medicineProportional hazards modelPopulationCognitionCohortCohort studyStatinGerontologyDiseaseConfidence intervalPsychiatryEnvironmental healthLipoproteins and Cardiovascular HealthAlzheimer's disease research and treatmentsComputational Drug Discovery Methods