Repurposing 9-Aminoacridine as an Adjuvant Enhances the Antimicrobial Effects of Rifampin against Multidrug-Resistant Klebsiella pneumoniae
Pengfei She, Yimin Li, Zehao Li, Shasha Liu, Yifan Yang, Linhui Li, Linying Zhou, Yong Wu
Abstract
without detected toxicity. 9-AA exerted its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. In summary, we found that 9-AA has the potential to be developed as a new antibacterial agent and adjuvant for RIF. Therefore, our study can reduce the risk of antimicrobial resistance and provide an option for the exploitation of new clinical drugs and a theoretical basis for the research on a new antimicrobial agent.
Topics & Concepts
Klebsiella pneumoniaeAntimicrobialMultiple drug resistanceMicrobiologyDrug resistanceDrug repositioningAntibiotic resistanceAntibioticsBiologyDrugPharmacologyEscherichia coliGeneBiochemistryAntibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and EfficacyCancer therapeutics and mechanisms