The Current Landscape of Oncolytic Herpes Simplex Viruses as Novel Therapies for Brain Malignancies
Joshua D. Bernstock, Samantha E. Hoffman, Jason Chen, Saksham Gupta, Ari D. Kappel, Timothy R. Smith, E. Antonio Chiocca
Abstract
Despite advances in surgical resection and chemoradiation, high-grade brain tumors continue to be associated with significant morbidity/mortality. Novel therapeutic strategies and approaches are, therefore, desperately needed for patients and their families. Given the success experienced in treating multiple other forms of cancer, immunotherapy and, in particular, immunovirotherapy are at the forefront amongst novel therapeutic strategies that are currently under investigation for incurable brain tumors. Accordingly, herein, we provide a focused mini review of pertinent oncolytic herpes viruses (oHSV) that are being investigated in clinical trials.