An acid-catalyzed 1,4-addition isocyanide-based multicomponent reaction in neat water
Jie Lei, Yong Li, Jia Xu, Dianyong Tang, Jingwei Shao, Hongyu Li, Zhong‐Zhu Chen, Zhigang Xu
Abstract
A 1,4-addition isocyanide-based three-component reaction was developed to synthesis chromanones derivatives with a green protocol, such as water solvent, simple operation, short reaction times, excellent yields and atom economy.
Topics & Concepts
CatalysisIsocyanideChemistryOrganic chemistryCombinatorial chemistryMulticomponent Synthesis of HeterocyclesSynthesis and biological activitySynthesis of Organic Compounds