Ketogenic diet attenuates cognitive dysfunctions induced by hypoglycemia <i>via</i> inhibiting endoplasmic reticulum stress-dependent pathways
Cixia Li, Yue Ma, Xuejun Chai, Xiao Feng, Wenyu Feng, Yongkang Zhao, Chaochu Cui, Jianguo Wang, Shanting Zhao, Xiaoyan Zhu
Abstract
decreased in KD-fed mice. KD can not only alleviate anxiety-like behavior induced by hypoglycemia, but also increase the proportion of mushroom dendritic spines in the hippocampus by modulating changes in the gut microbiota. KD regulated synaptic plasticity by increasing the levels of SPN, PSD95, and SYP, which relieve cognitive impairment caused by hypoglycemia. Moreover, KD can promote the proliferation and survival of adult neural stem cells in the hippocampus, while reducing apoptosis by suppressing the activation of the IRE1-XBP1 and ATF6 endoplasmic reticulum stress pathways in mice with hypoglycemia. This study provides new evidence for demonstrating that KD may alleviate cognitive dysfunctions caused by hypoglycemia by modulating the gut microbiota.