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Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control

Sarah A. Weiss, Amy Y. Huang, Megan E. Fung, Daniela Martínez, Chang-Yu Chen, Thomas J. LaSalle, Brian C. Miller, Christopher D. Scharer, Mudra Hegde, Thao H. Nguyen, Jared H. Rowe, Jossef F. Osborn, Dillon G. Patterson, Natalia E. Sifnugel, Mei-An Nolan, Richard A. Davidson, Marc A. Schwartz, Alexander P. R. Bally, Dennis K. Neeld, Martin W. LaFleur, Jeremy M. Boss, John G. Doench, W. Nicholas Haining, Arlene H. Sharpe, Debattama R. Sen

2024Nature Immunology42 citationsDOIOpen Access PDF

Topics & Concepts

EpigeneticsRegulatorFunction (biology)Negative regulatorCell biologyBiologyMaster regulatorComputational biologyGeneticsGeneTranscription factorSignal transductionImmune Cell Function and InteractionCancer Immunotherapy and BiomarkersImmune cells in cancer
Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control | Litcius