Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control
Sarah A. Weiss, Amy Y. Huang, Megan E. Fung, Daniela Martínez, Chang-Yu Chen, Thomas J. LaSalle, Brian C. Miller, Christopher D. Scharer, Mudra Hegde, Thao H. Nguyen, Jared H. Rowe, Jossef F. Osborn, Dillon G. Patterson, Natalia E. Sifnugel, Mei-An Nolan, Richard A. Davidson, Marc A. Schwartz, Alexander P. R. Bally, Dennis K. Neeld, Martin W. LaFleur, Jeremy M. Boss, John G. Doench, W. Nicholas Haining, Arlene H. Sharpe, Debattama R. Sen
Topics & Concepts
EpigeneticsRegulatorFunction (biology)Negative regulatorCell biologyBiologyMaster regulatorComputational biologyGeneticsGeneTranscription factorSignal transductionImmune Cell Function and InteractionCancer Immunotherapy and BiomarkersImmune cells in cancer