Design and synthesis of harmiquins, harmine and chloroquine hybrids as potent antiplasmodial agents
Goran Poje, Laís Pessanha de Carvalho, Jana Held, Diana Moita, Miguel Prudêncio, Ivana Perković, Tana Tandarić, Robert Vianello, Zrinka Rajić
Topics & Concepts
Plasmodium falciparumChemistryChloroquineIC50HemeMechanism of actionPharmacologyAntimalarial AgentLinkerStereochemistryBiochemistryMalariaIn vitroEnzymeBiologyImmunologyComputer scienceOperating systemSynthesis and bioactivity of alkaloidsHIV/AIDS drug development and treatmentSynthesis and Biological Evaluation