Genetic Variation in Cardiometabolic Traits and Medication Targets and the Risk of Hypertensive Disorders of Pregnancy
Michael C. Honigberg, Mark Chaffin, Krishna G. Aragam, Deepak L. Bhatt, Malissa J. Wood, Amy Sarma, Nandita S. Scott, Gina M. Peloso, Pradeep Natarajan
Abstract
genome-wide association study genetic predisposition to disease hypertension, pregnancy-induced H ypertensive disorders of pregnancy (HDPs; eg, gestational hypertension, preeclampsia) are associated with significant maternal and fetal morbidity and mortality. In addition, HDPs are associated with heightened future risk of cardiometabolic risk factors (eg, hypertension, type 2 diabetes mellitus [T2D]) and cardiovascular disease. Whether HDPs reflect latent preceding cardiometabolic risk is unclear. Here, we tested whether genetic predisposition to cardiometabolic traits and variants related to antihypertensive medication targets are associated with HDPs.