PIM1/NF-κB/CCL2 blockade enhances anti-PD-1 therapy response by modulating macrophage infiltration and polarization in tumor microenvironment of NSCLC
Xiuqiong Chen, Jing Zhou, Youhui Wang, Xinyue Wang, Kaidi Chen, Qin Chen, Dingzhi Huang, Richeng Jiang
Topics & Concepts
PIM1Cancer researchTumor microenvironmentCCL2BiologyMacrophage polarizationChemokineImmunotherapyImmune systemImmunologyMacrophageCell biologyPhosphorylationIn vitroBiochemistrySerineCancer Mechanisms and TherapyPhagocytosis and Immune RegulationPeptidase Inhibition and Analysis