Thrombolysis by PLAT/tPA increases serum free IGF1 leading to a decrease of deleterious autophagy following brain ischemia
Audrey M. Thiebaut, Izaskun Buendía, Vanessa Ginet, Eloïse Lemarchand, Mehdi Boutagouga Boudjadja, Yannick Hommet, Laurent Lebouvier, Lechevallier Charlotte, Mike Maillasson, Élodie Hedou, Nicole Déglon, Franck Oury, Marina Rubio, Joan Montaner, Julien Puyal, Denis Vivien, Benoit D. Roussel
Abstract
: oxygen and glucose deprivation + reoxygentation; PepA: pepstatin A1; PI3K: phosphoinositide 3-kinase; PLAT/tPA: plasminogen activator, tissue; PPP: picropodophyllin; SCH77: SCH772984; ULK1: unc-51 like kinase 1; Wort: wortmannin.
Topics & Concepts
AutophagyProteostasisNeuroprotectionPI3K/AKT/mTOR pathwayBiologyInsulin-like growth factor 1 receptorLRP1MitophagyPharmacologyGrowth factorIschemiaCell biologyReceptorEndocrinologyInternal medicineApoptosisMedicineSignal transductionBiochemistryLDL receptorLipoproteinCholesterolAutophagy in Disease and TherapyCancer-related molecular mechanisms researchLipid metabolism and disorders