Design, synthesis, and biological evaluation of novel quinoline derivatives as small molecule mutant EGFR inhibitors targeting resistance in NSCLC: In vitro screening and ADME predictions
Ramakant A. Kardile, Aniket P. Sarkate, Deepak K. Lokwani, Shailee V. Tiwari, Rajaram Azad, Shankar R. Thopate
Topics & Concepts
ADMEChemistryProtein Data Bank (RCSB PDB)Allosteric regulationDocking (animal)Lipinski's rule of fiveLead compoundOsimertinibEnzymeBiochemistryIn silicoStereochemistryIn vitroEpidermal growth factor receptorErlotinibReceptorMedicineGeneNursingBiochemical and Molecular ResearchCancer therapeutics and mechanismsSynthesis and biological activity