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Tazemetostat synergistically combats multidrug resistance by the unique triple inhibition of ABCB1, ABCC1, and ABCG2 efflux transporters in vitro and ex vivo

Youssif Budagaga, Ziba Sabet, Yu Zhang, Eva Novotná, Ivo Hanke, Tomáš Rozkoš, Jakub Hofman

2023Biochemical Pharmacology15 citationsDOI

Topics & Concepts

PharmacologyMedicineABCC1ATP-binding cassette transporterAbcg2Multiple drug resistanceEffluxDrug resistanceTransporterBiologyBiochemistryGeneMicrobiologyDrug Transport and Resistance MechanismsCancer therapeutics and mechanismsHIV/AIDS drug development and treatment
Tazemetostat synergistically combats multidrug resistance by the unique triple inhibition of ABCB1, ABCC1, and ABCG2 efflux transporters in vitro and ex vivo | Litcius