Quantitative genome-scale metabolic modeling of human CD4+ T cell differentiation reveals subset-specific regulation of glycosphingolipid pathways
Partho Sen, Syed Bilal Ahmad Andrabi, Tanja Buchacher, Mohd Moin Khan, Ubaid Ullah, Tuomas Lindeman, Marina Amaral Alves, Victoria Hinkkanen, Esko Kemppainen, Alex M. Dickens, Omid Rasool, Tuulia Hyötyläinen, Riitta Lahesmaa, Matej Orešič
Abstract
T cells under disease conditions characterized by an imbalance of Th17/natural Treg (nTreg) cells.
Topics & Concepts
BiologyGene knockdownCellular differentiationCell biologySphingolipidGlycosphingolipidEffectorReprogrammingMetabolic pathwayT cellGeneGeneticsImmune systemImmune Cell Function and InteractionT-cell and B-cell ImmunologySphingolipid Metabolism and Signaling