Enhancing the dissolution and bacteriostatic activity of trimethoprim through salt formation
Xingchen Hu, Yuntian Xiao, Luguang Qi, Yunhe Bai, Ying Sun, Yang Ye, Chuang Xie
Abstract
Trimethoprim (TMP) is a commonly used BCS class II antibiotic, the water solubility of which needs to be improved to overcome the limitations in oral administration.
Topics & Concepts
DissolutionTrimethoprimSolubilitySalt (chemistry)ChemistryAntibioticsCombinatorial chemistryOrganic chemistryBiochemistryPhenothiazines and Benzothiazines Synthesis and ActivitiesDrug Solubulity and Delivery SystemsCrystallization and Solubility Studies