Structure-based discovery and development of novel O-GlcNAcase inhibitors for the treatment of Alzheimer's disease
Xiaoli Li, Jinhe Han, Sheshurao Bujaranipalli, Jie He, Eun Young Kim, Hee Yeon Kim, Jae Hong Im, Won‐Jea Cho
Topics & Concepts
ChemistryHyperphosphorylationTau proteinDocking (animal)Cognitive declineAlzheimer's diseaseStructure–activity relationshipBiochemistryBlood–brain barrierLead compoundPharmacologyPhosphorylationDementiaIn vitroDiseaseInternal medicineNursingCentral nervous systemMedicineGlycosylation and Glycoproteins ResearchCarbohydrate Chemistry and SynthesisLysosomal Storage Disorders Research