Coordination-based self-assembled capsules (SACs) for protein, CRISPR–Cas9, DNA and RNA delivery
Lukman O. Alimi, Mram Alyami, Santanu Chand, Walaa S. Baslyman, Niveen M. Khashab
Abstract
stability, on-demand biodegradability, high encapsulation efficiency, easy surface modification and moderate synthetic conditions. Consequently, these systems have been extensively utilized as carriers of biomacromolecules for biomedical applications. This review summarizes the recent applications of nMOFs and coordination cages for protein, CRISPR-Cas9, DNA and RNA delivery. We also highlight the progress and challenges of coordination-based platforms as a promising approach towards clinical biomacromolecule delivery and discuss integral future research directions and applications.
Topics & Concepts
CRISPRCas9RNADNAComputational biologyBiologyGuide RNAChemistryCell biologyGeneticsGeneSupramolecular Self-Assembly in MaterialsAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene Delivery