Synthesis and anti-inflammatory evaluation of new chalcone derivatives bearing bispiperazine linker as IL-1β inhibitors
Yanling Tang, Xi Zheng, Qi Yan, Xiao-Jia Pu, Bei Liu, Xia Zhang, Xiao-Si Li, Wei‐Lie Xiao, Chunping Wan, Zewei Mao
Topics & Concepts
ChalconeChemistryLinkerCytotoxicityInflammasomeAnti-inflammatoryCytotoxic T cellIn vitroIC50StereochemistryCombinatorial chemistryPharmacologyBiochemistryReceptorOperating systemMedicineComputer scienceInflammasome and immune disordersMacrophage Migration Inhibitory FactorCardiovascular, Neuropeptides, and Oxidative Stress Research