BRD4 inhibition induces synthetic lethality in ARID2-deficient hepatocellular carcinoma by increasing DNA damage
Dan-Dan He, Xue-Ying Shang, Na Wang, Guang-Xing Wang, Kun-Yan He, Lan Wang, Ze-Guang Han
Topics & Concepts
Synthetic lethalityBRD4DNA damageChromatinBiologyCancer researchHCCSHomologous recombinationBromodomainDNA repairDNAChromatin remodelingGeneMutationGenome instabilityPARP1Transcription (linguistics)Molecular biologyTranscription factorCellCell biologyProgrammed cell deathHistoneGeneticsNuclear proteinEpigeneticsG2-M DNA damage checkpointChromatin Remodeling and CancerProtein Degradation and InhibitorsGenomics and Chromatin Dynamics