Discovery of a nitroaromatic nannocystin with potent in vivo anticancer activity against colorectal cancer by targeting AKT1
Han Zhang, Fei Xie, Xiaoya Yuan, Xin-tong Dai, Yunfeng Tian, Ming-ming Sun, Siqi Yu, Jiayou Cai, Bin Sun, Weicheng Zhang, Changliang Shan
Topics & Concepts
In vivoColorectal cancerApoptosisCancerCell cycleDepsipeptideCell cultureCell growthChemistryCell cycle checkpointCancer researchIn vitroGrowth inhibitionPharmacologyBiologyStereochemistryMedicineBiochemistryInternal medicineGeneticsBiotechnologyProtist diversity and phylogenyAquatic Ecosystems and Phytoplankton DynamicsMicrobial Community Ecology and Physiology