The Photochemical Activity of a Halogen-Bonded Complex Enables the Microfluidic Light-Driven Alkylation of Phenols
Sara Cuadros, Cristian Rosso, Giorgia Barison, Paolo Costa, Marina Kurbasic, Marcella Bonchio, Maurizio Prato, Giacomo Filippini, Luca Dell’Amico
Abstract
generated electron-rich phenolate anion with the α-iodosulfone. The reaction proceeds rapidly (10 min) under microfluidic conditions, delivering a wide variety of ortho-alkylated products (27 examples, up to 97% yield, >20:1 regioselectivity, on a gram scale), including densely functionalized bioactive phenol derivatives.
Topics & Concepts
ChemistryAlkylationHalogenPhenolsPhotochemistryOrganic chemistryCatalysisAlkylRadical Photochemical ReactionsFluorine in Organic ChemistryAdvanced Chemical Sensor Technologies